Dr Lewis Bingle


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Senior Lecturer

I have over two decades of experience as a molecular microbiologist and a wide range of interests, especially in the areas of causation (pathogenicity) and treatment (antimicrobial drugs and antibiotic resistance) of infectious disease.

Teaching and supervision

I teach on BSc (Hons) Biomedical Science and some postgraduate courses mainly in the areas of microbiology or molecular biology.

Research interests for potential research students

My main research interests at the moment are the discovery of novel antimicrobial natural products from bacteria and transcriptional regulation of host interaction functions in Gram-negative bacteria.

I am able to supervise research in other areas of molecular microbiology - please contact me to discuss.

Research

I have worked on a wide-range of topics in microbiology over the years mostly focussing on molecular genetics. My main current research interests are as follows:

  • Discovery of novel antimicrobial natural products from bacteria using a combination of lab-based microbiology and genomics approaches
  • Transcriptional regulation of host interaction functions in Gram-negative bacteria (mainly E. coli).

Publications

Number of items: 16.

Article

Vasireddy, Lakshmi, Bingle, Lewis and Davies, Mark (2018) Antimicrobial activity of essential oils against multidrug-resistant clinical isolates of the Burkholderia cepacia complex. PLoS ONE.

Hayes, Catherine, Fulton, John, Devlin, Siobhan, Westwood, Diane, Garfield, Iain, Beardmore, Phil, Archer, David, Collins, Michael and Bingle, Lewis (2016) Perception of academic learning environments and perceived impact on articulation of employability; a mixed methods study. Journal of Learning Development in Higher Education (10). ISSN 1759-667X

Rajasekar, K V, Lovering, A L, Dancea, F, Scott, D J, Harris, S A, Bingle, Lewis, Roessle, M, Thomas, C M, Hyde, E I and White, S A (2016) Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator. Nucleic Acids Research, 1. ISSN 0305-1048

Heussner, A.H. and Bingle, Lewis (2015) Comparative ochratoxin toxicity: a review of the available data. Toxins, 7 (10). pp. 4253-4282. ISSN 2072-6651

Bingle, Lewis, Constantinidou, Chrystala, Shaw, Robert K., Islam, Shahidul, Patel, Mala, Snyder, Lori A. S., Lee, David J., Penn, Charles W., Busby, Stephen J. W. and Pallen, Mark J, (2014) Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains. PLOS One, 9 (1). e80160. ISSN 1932-6203

Islam, Md. Shahidul, Bingle, Lewis, Pallen, Mark J and Busby, Stephen J W (2011) Organization of the LEE1 operon regulatory region of enterohaemorrhagic escherichia coli O157:H7 and activation by GrlA. Molecular Microbiology, 79 (2). pp. 468-483. ISSN 0950-382X

Younis, Rasha, Bingle, Lewis, Rollauer, Sarah, Munera, Diana, Busby, Stephen J W, Johnson, Steven, Deane, Janet E, Lea, Susan M, Frankel, Gad and Pallen, Mark J (2010) SepL resembles an aberrant effector in binding to a class 1 type-III secretion chaperone and carrying an N-terminal secretion. Journal of Bacteriology, 192 (22). pp. 6093-6098. ISSN 0021-9193

Lewis, T, Loman, N J, Bingle, Lewis, Jumaa, P, Weinstock, G M, Mortiboy, D and Pallen, Mark J (2010) High-throughput whole-genome sequencing to dissect the epidemiology of acinetobacter baumannii isolates from a hospital outbreak. Journal of Hospital Infection, 75 (1). pp. 37-41. ISSN 0195-6701

Lee, D J, Bingle, Lewis, Heurlier, K, Pallen, Mark J, Penn, C W, Busby, Stephen J W and Hobman, J L (2009) Gene doctoring: a method of recombineering in laboratory and pathogenic escherichia coli strains. BMC Microbiology, 9. p. 252. ISSN 1471-2180

Fernando, C T, Liekens, A M, Bingle, Lewis, Beck, C, Lenser, T, Stekel, D J and Rowe, Jonathan E (2009) Molecular circuits for associative learning in single-celled organisms. Journal of the Royal Society Interface, 6 (34). pp. 463-469. ISSN 1742-5689

Batt, S M, Bingle, Lewis, Dafforn, T R and Thomas, C M (2009) Bacterial Genome Partitioning: N-Terminal Domain of IncC Protein Encoded by Broad-Host-Range Plasmid RK2 Modulates Oligomerisation and DNA Binding. Journal of Molecular Biology, 385 (5). pp. 1361-1374. ISSN 0022-2836

Bingle, Lewis, Rajasekar, K V, Muntaha, S T, Nadella, V, Hyde, E I and Thomas, C M (2008) A single aromatic residue in transcriptional repressor protein KorA is critical for co-operativity with its co-regulator KorB. Molecular Microbiology, 70 (6). pp. 1502-1514. ISSN 0950-382X

Sevastsyanovich, Y R, Krasowiak, R, Bingle, Lewis, Haines, A S, Sokolov, S L, Kosheleva, I A, Leuchuk, A A, Titok, M A, Smalla, K and Thomas, C M (2008) Diversity of IncP-9 plasmids of Pseudomonas. Microbiology, 154 (10). pp. 2929-2941. ISSN 1350-0872

Chiu, C, Manzoor, S E, Batt, S M, Tul Muntaha, S, Bingle, Lewis and Thomas, C M (2008) Distribution of the partitioning protein KorB on the genome of IncP-1 plasmid RK2. Plasmid, 59 (3). pp. 163-175. ISSN 0147-619X

Bingle, Lewis, Bailey, Christopher M and Pallen, Mark J (2008) Type VI secretion: a beginner's guide. Current Opinion in Microbiology, 11 (1). pp. 3-8. ISSN 1369-5274

Book Section

Bingle, Lewis, Hayes, Catherine and Miller, E. (2017) Infection Control and Microbiology. In: Textbook of Podiatric Medicine. M&K Publishing. ISBN 9781905539321

This list was generated on Sun Mar 24 18:14:25 2019 GMT.

Areas of expertise

  • Analysis of gene expression / promoter activity (e.g. using reporter gene assays)
  • Heterologous protein expression and purification in E. coli
  • Site-directed mutagenesis in E. coli and related bacteria
  • Phylogenetic analysis
  • Bacterial identification using traditional (lab-based) and molecular approaches

Further information

Last updated 27 September 2018