Dr Svetlana Mysina


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Academic Tutor

I qualified in Biology and Human Genetics (1995- 2000) and  received my PhD at the University of Tübingen, Germany (2004).

My postdoctoral career in cancer research began in Tubingen in 2004 and continued in Glasgow where I was led a project in Chronic Meyloid Leukaemia. I then went on to the Northern Institute for Cancer Research at Newcastle University investigating the mechanism of paediatric leukaemia.

I have comprehensive teaching experience in a broad range of biological disciplines lecturing at the University of Tubingen, University of Glasgow, Newcastle University, Northumbria University and I became a Fellow of the Higher Education Academy.

I am active in cancer research with my main interests in molecular mechanisms and drug resistance in neuroblastoma.

Teaching and supervision

I teach the following modules on BSc (Hons) Biomedical Science and BSc (Hons) Physiological Sciences.

  • Human Physiology 
  • Chemistry for Biosciences
  • Microbes, Immunology
  • Clinical and Professional Practice for Healthcare Science
  • Pathophysiology and Therapeutics
  • Blood Science
  • Molecular and Cellular Analysis
  • Cellular Pathology
  • Medical Microbiology
  • Haematology and Transfusion Science

Research interests for potential research students

  • Cell signalling in cancer stem cells 
  • Leukaemia
  • Neuroblastoma

Research

During my research career, I have developed a strong research portfolio with excellent project management skills. I have made a substantial contribution to the field of cancer and published 22 papers in high quality international journals.

My current research interest is within drug resistance in neuroblastoma. We have currently submitted two manuscripts on neuroblastoma research.

I am active in academic research and I also maintain an interest in pedagogical research and development of innovating education. 

Publications

Number of items: 23.

Article

Elsana, Hassan, Mysina, Svetlana, Elkordy, Emal Ali, Carr-Wilkinson, Jane and Elkordy, Amal (2018) Insights into the influences of carboxymethyl-β-cyclodextrin on DNA formulations characteristics and gene transfection efficiency. Current Drug Delivery, 15. ISSN 1567 2018

Hamilton, Ashley, Helgason, G Vignir, Schemionek, Mirle, Zhang, Bin, Mysina, Svetlana, Allan, Elaine K, Nicolini, Franck E, Müller-Tidow, Carsten, Bhatia, Ravi, Brunton, Valerie G, Koschmieder, Steffen and Holyoake, Tessa L (2012) Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood, 119 (6). pp. 1501-10. ISSN 1528-0020

Hamilton, Ashley, Alhashimi, Fatma, Mysina, Svetlana, Jorgensen, Heather G and Holyoake, Tessa L (2009) Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells. Experimental hematology, 37 (3). pp. 395-401. ISSN 1873-2399

Mysina, Svetlana, Helgason, G Vignir, Serrels, Alan, Jørgensen, Heather G, Bhatia, Ravi, Modi, Hardik, Baird, Janet W, Mountford, Joanne C, Hamilton, Ashley, Schemionek, Mirle, Koschmieder, Steffen, Brunton, Valerie G and Holyoake, Tessa L (2009) Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Experimental hematology, 37 (2). pp. 206-14. ISSN 1873-2399

Hamilton, A, Elrick, L, Mysina, Svetlana, Copland, M, Jørgensen, H, Melo, J V and Holyoake, T (2006) BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. Leukemia, 20 (6). pp. 1035-9. ISSN 0887-6924

Hamilton, A, Elrick, L, Mysina, Svetlana, Copland, M, Jørgensen, H, Melo, J V and Holyoake, T (2006) BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. Leukemia, 20 (6). pp. 1035-9. ISSN 0887-6924

Shumilina, Ekaterina, Lampert, Angelika, Lupescu, Adrian, Mysina, Svetlana, Strutz-Seebohm, Nathalie, Henke, Guido, Grahammer, Florian, Wulff, Peer, Kuhl, Dietmar and Lang, Florian (2005) Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. Journal of cellular physiology, 204 (1). pp. 87-98. ISSN 0021-9541

Lang, P A, Kempe, D S, Mysina, Svetlana, Tanneur, V, Birka, C, Laufer, S, Lang, F, Wieder, T and Huber, S M (2005) PGE(2) in the regulation of programmed erythrocyte death. Cell death and differentiation, 12 (5). pp. 415-28. ISSN 1350-9047

Baltaev, Ravshan, Strutz-Seebohm, Nathalie, Korniychuk, Ganna, Mysina, Svetlana, Lang, Florian and Seebohm, Guiscard (2005) Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Archiv : European journal of physiology, 450 (1). pp. 26-33. ISSN 0031-6768

Lang, Philipp A, Kempe, Daniela S, Tanneur, Valerie, Eisele, Kerstin, Klarl, Barbara A, Mysina, Svetlana, Jendrossek, Verena, Ishii, Satoshi, Shimizu, Takao, Waidmann, Marc, Hessler, Gabriele, Huber, Stephan M, Lang, Florian and Wieder, Thomas (2005) Stimulation of erythrocyte ceramide formation by platelet-activating factor. Journal of cell science, 118 (Pt 6). pp. 1233-43. ISSN 0021-9533

Birka, Christina, Lang, Philipp A, Kempe, Daniela S, Hoefling, Lena, Tanneur, Valerie, Duranton, Christophe, Nammi, Srinivas, Henke, Guido, Mysina, Svetlana, Krikov, Maxim, Huber, Stephan M, Wieder, Thomas and Lang, Florian (2004) Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion. Pflugers Archiv : European journal of physiology, 448 (5). pp. 471-7. ISSN 0031-6768

Lang, Karl S, Mysina, Svetlana, Lang, Philipp A, Tanneur, Valerie, Kempe, Daniela S, Mack, Andreas F, Huber, Stephan M, Wieder, Thomas, Lang, Florian and Duranton, Christophe (2004) Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-. American journal of physiology. Renal physiology, 286 (6). F1046-53. ISSN 1931-857X

Lang, Philipp A, Kaiser, Stephanie, Mysina, Svetlana, Birka, Christina, Weinstock, Christof, Northoff, Hinnak, Wieder, Thomas, Lang, Florian and Huber, Stephan M (2004) Effect of Vibrio parahaemolyticus haemolysin on human erythrocytes. Cellular microbiology, 6 (4). pp. 391-400. ISSN 1462-5814

Lang, K S, Mysina, Svetlana, Brand, V, Sandu, C, Lang, P A, Berchtold, S, Huber, S M, Lang, F and Wieder, T (2004) Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell death and differentiation, 11 (2). pp. 231-43. ISSN 1350-9047

Mysina, Svetlana, Lang, Philipp A, Kempe, Daniela S, Kaiser, Stefanie, Huber, Stephan M, Wieder, Thomas and Lang, Florian (2004) Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 14 (4-6). pp. 241-8. ISSN 1015-8987

Lang, Philipp A, Kaiser, Stefanie, Mysina, Svetlana, Wieder, Thomas, Lang, Florian and Huber, Stephan M (2003) Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. American journal of physiology. Cell physiology, 285 (6). C1553-60. ISSN 0363-6143

Lang, Florian, Lang, Karl S, Wieder, Thomas, Mysina, Svetlana, Birka, Christina, Lang, Philipp A, Kaiser, Stephanie, Kempe, Daniela, Duranton, Christophe and Huber, Stephan M (2003) Cation channels, cell volume and the death of an erythrocyte. Pflugers Archiv : European journal of physiology, 447 (2). pp. 121-5. ISSN 0031-6768

Mysina, Svetlana, Huber, Stephan M, Birka, Christina, Lang, Philipp A, Lang, Karl S, Friedrich, Björn, Risler, Teut, Wieder, Thomas and Lang, Florian (2003) Inhibition of erythrocyte cation channels by erythropoietin. Journal of the American Society of Nephrology : JASN, 14 (11). pp. 2750-7. ISSN 1046-6673

Lang, K S, Mysina, Svetlana, Tanneur, V, Wieder, T, Huber, S M, Lang, F and Duranton, C (2003) Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn-Schmiedeberg's archives of pharmacology, 367 (4). pp. 391-6. ISSN 0028-1298

Lang, K S, Duranton, C, Poehlmann, H, Mysina, Svetlana, Bauer, C, Lang, F, Wieder, T and Huber, S M (2003) Cation channels trigger apoptotic death of erythrocytes. Cell death and differentiation, 10 (2). pp. 249-56. ISSN 1350-9047

Lang, Philipp A, Warskulat, Ulrich, Heller-Stilb, Birgit, Huang, Dan Y, Grenz, Almut, Mysina, Svetlana, Duszenko, Michael, Lang, Florian, Häussinger, Dieter, Vallon, Volker and Wieder, Thomas (2003) Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 13 (6). pp. 337-46. ISSN 1015-8987

Lang, Karl S, Roll, Benjamin, Mysina, Svetlana, Schittenhelm, Markus, Scheel-Walter, Hans-Gerhard, Kanz, Lothar, Fritz, Jasmin, Lang, Florian, Huber, Stephan M and Wieder, Thomas (2002) Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 12 (5-6). pp. 365-72. ISSN 1015-8987

Conference or Workshop Item

Mysina, Svetlana, Ahmed, Shafiq, Michaelis, Martin, Cinatl Jr, Jindrich, Adejuwon, Damilola, Zaka, Masood and Carr-Wilkinson, Jane (2018) Investigating the role of cancer stem cell related genes in acquired drug resistance in neuroblastoma. In: Advances in Neuroblastoma Research 2018, May 9th -12th 2018, San Francisco.

This list was generated on Sun Mar 24 18:17:47 2019 GMT.

Areas of expertise

My areas of expertise are in molecular mechanisms of cancer, Leukaemia, and Neuroblastoma

I have a broad range of research expertise including molecular biological and immunological techniques such as gene editing, gene overexpression and knockdown, flow cytometry, immunocytochemistry, immunohistochemistry, immunoblotting and principles of physiological/electrophysiological methods e.g. patch clamp.

Last updated 18 October 2018