Head of School: Pharmacy and Pharmaceutical Sciences
Teaching and supervision
Research interests for potential research students
Research
I have a background in organic chemistry and have worked in both academia and industry. I have acted as Director of Studies for post-doctoral workers, PhD students and MPhil students and contributed to over 70 publications in peer reviewed journals, four chapters in major edited works and one patent.
Current research areas of interest involve aspects of heterocyclic and organosulfur chemistry; in particular:
(a) The synthesis of natural product analogues with potential use in treatment of, for example (i) neurodegenerative diseases (development of nicotinic receptor agonist, secretase enzyme inhibitors), (ii) pain, opiate addiction and smoking cessation (development of nicotinic receptor agonists/antagonists), (iii) depression (development of melatonin receptor agonist and serotonin receptor antagonists), and (iv) anti-cancer activity (synthesis of analogoues of marine derived pyrrolo, pyridino and quinolino-alkaloids and investigation of their cytotoxic activity, particularly topoisomerase I and II inhibition). Pre-clinical pharmacological investigations.
(b) Synthesis of novel supramolecular systems containing covalently and conjugatively linked redox systems (use as potential electron transfer catalysts as mimics of biological redox processes).
(c) Synthesis of dendrimers bearing macrocycle receptors coupled to redox centres to afford supported redox-active molecular recognition units (use as electron transfer catalysts as mimics of biological redox processes and for studies on dynamics of metal cation transport at membrane surfaces).
(d) Metal aggregates of ligating donor atom rich ligands as complexing agents for alkali metals, p- and d-block elements (use in metal ion transport through membranes and uptake and release processes in living organisms).Publications
Article
Haj-Ahmad, Rita, Elkordy, Amal, Chaw, Cheng and Moore, Adrian (2013) Compare and contrast the effects of surfactants (Pluronic®F-127 and Cremophor®EL) and sugars (beta-cyclodextrin and inulin) on properties of spray dried and crystallised lysozyme. European Journal of Pharmaceutical Sciences, 49 (4). pp. 519-534. ISSN 0928-0987
Todd, Adam, Moore, Adrian, Ashton, Mark and Van, Son (2010) Current research and development of treatments for Alzheimer’s disease. The Pharmaceutical Journal, 284 (7599). pp. 429-430. ISSN 0031-6873
Anderson, Rosaleen, Groundwater, Paul, Moore, Adrian and Todd, Adam (2009) An overview of cancer treatments. The Pharmaceutical Journal, 283. pp. 511-512. ISSN 0031-6873
Perepichka, D F, Perepichka, I F, Ivasenko, O, Moore, Adrian, Bryce, M R, Kuz'mina, L G, Batsanov, Andrei S and Sokolov, N I (2008) Combining high electron affinity and intramolecular charge transfer in 1, 3-dithiole-nitrofluorene push-pull diads. Chemistry - A European Journal, 14 (9). pp. 2757-270. ISSN 0947-6539
Moore, Adrian, Bryce, M R, Batsanov, Andrei S and Finn, T (2001) Crown-annelated 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene derivatives as cation sensors: Synthesis, x-ray crystal structures, voltammetric and spectroscopic monitoring of metal complexation. European Journal of Organic Chemistry, 14. pp. 933-940. ISSN 1434193X
Moore, Adrian, Batsanov, Andrei S, Bryce, M R and Chesney, A (2001) Synthesis and crystal engineering of new halogenated tetrathiafulvalene (TTF) derivatives and their charge transfer complexes and radical ion salts. Journal of Materials Chemistry, 11 (9). pp. 2181-2191. ISSN 09599428
Moore, Adrian, Bryce, M R, Green, Andrew and Perepichka, D F (2001) Synthesis of conjugated tetrathiafulvalene (TTF)-pi-acceptor molecules - intramolecular charge transfer and nonlinear optical properties. European Journal of Organic Chemistry (10). pp. 1927-1935. ISSN 1434193X
Moore, Adrian, Chesney, A, Bryce, M R and Batsanov, Andrei S (2001) Synthesis, structures and nonlinear optical properties of novel D-pi-A chromophores: intramolecular charge transfer from 1,3-dithiole and ferrocene moieties to polynitrofluorene or dicyanomethylene moieties through conjugated linkers. European Journal of Organic Chemistry, 14. pp. 2671-2687. ISSN 1434193X
Book Section
Hayes, Catherine and Moore, Adrian (2020) Driving the Capture of Faculty Pedagogical Activity Excellence via a Systematic Methodological Approach: A Case Study of RE-AIM Hybrid Adaptation in a UK Higher Education Institution. In: SAGE Research Methods Case Studies. Sage Publications, USA. (In Press)
Moore, Adrian (2008) Bicyclic 5-5 Systems: Three Heteroatoms 1:2. In: Comprehensive Heterocyclic Chemistry III. Elsevier, Oxford. ISBN 978-0080449913
Conference or Workshop Item
Haj-Ahmad, Rita, Chaw, Cheng, Elkordy, Amal and Moore, Adrian (2013) Stabilizing effect of surfactants and saccharides on freeze dried lysozyme. In: UK-PharmSci 2013 conference, 2 - 4 Sep 2013, Edinburgh, UK..
Haj-Ahmad, Rita Rochdi, Chaw, Cheng, Elkordy, Amal and Moore, Adrian (2012) Pluronic F-127 as a constituent of niosomes as a novel delivery system for Insulin. In: UK PharmSci 2012 conference, September 12-14th, 2012, East Midlands Conference Centre, Nottingham University, Nottingham, UK.. (Unpublished)
Haj Ahmad, R, Chaw, Cheng, Moore, Adrian and Elkordy, Amal (2011) Effect of excipients on lysozyme crystals. In: The Science of Medicines: UK Pharmsci 2011, 31 Aug - 2 Sep 2011, East Midlands Conference Centre, Nottingham University, Nottingham. (Unpublished)
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