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Senior Lecturer in Medicinal Chemistry

I teach on the following courses:
MPharm Pharmacy
BSc Biopharmaceutical Science
BSc Cosmetic Science
MSc Drug Discovery and Development


Teaching and supervision

I teach modules on organic chemistry, thermodynamics, physical organic chemistry, bioorganic chemistry, medicinal chemistry, rational drug design, and molecular modelling.

Research interests for potential research students

Synthetic chemistry, physical organic chemistry, bioorganic chemistry, medicinal chemistry, rational drug design, and molecular modelling.

Publications

Number of items: 17.

Article

Ng, Keng Tiong, Perry, John D., Marrs, Emma C.L., Orenga, Sylvain, Anderson, Rosaleen J. and Gray, Mark (2020) Synthesis and Antimicrobial Activity of Phosphonopeptide Derivatives Incorporating Single and Dual Inhibitors. Molecules, 25 (7). e1557. ISSN 1420-3049

Marrs, Emma C.L., Varadi, Linda, Bedernjak, Alexandre F., Day, Kathryn M., Gray, Mark, Jones, Amanda L., Cummings, Stephen P., Anderson, Rosaleen J. and Perry, John D. (2020) Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance. Molecules, 25 (6). e1445. ISSN 1420-3049

Kondacs, Laszlo A., Orenga, Sylvain, Anderson, Rosaleen J., Marrs, Emma C.L., Perry, John D. and Gray, Mark (2020) C-Terminal 1-Aminoethyltetrazole-Containing Oligopeptides as Novel Alanine Racemase Inhibitors. Molecules, 25 (6). e1315. ISSN 1420-3049

Bedernjak, Alexandre, Groundwater, Paul, Gray, Mark, Orenga, S, Perry, J D and Anderson, Rosaleen (2013) Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria. Tetrahedron, 69 (39). pp. 8456-8462. ISSN 0040-4020

Kottakota, Suresh, Benton, Matthew, Evangelopoulos, D, Guzman, J. D., Bhakta, S, McHugh, T. D., Groundwater, P. W., Gray, Mark, Marrs, E. C. L., Perry, J. D. and Harburn, J. J. (2012) Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines. Organic Letters, 14 (24). pp. 6310-6313. ISSN 1523-7060

Tindle, John, Gray, Mark, Warrender, Robert, Ginty, Kevin and Dawson, Peter (2012) Application Framework for Computational Chemistry (AFCC) applied to New Drug Discovery. International Journal of Grid and High-Performance Computing, 4 (2). pp. 46-62. ISSN 1938-0259

Kottakota, S K, Evangelopoulos, D, Alnimr, A, Bhakta, S, McHugh, T, Gray, Mark, Groundwater, Paul, Marrs, E C L, Perry, J D, Spilling, C D and Harburn, J J (2012) Synthesis and Biological Evaluation of Purpurealidin E-Derived Marine Sponge Metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B. Journal of Natural Products, 75 (6). pp. 1090-1101. ISSN 0163-3864

Varadi, Linda, Gray, Mark, Groundwater, Paul, Hall, Andrew, James, Arthur L, Orenga, Sylvain, Perry, John D and Anderson, Rosaleen (2012) Synthesis and evaluation of fluorogenic 2-amino-1,8-naphthyridine derivatives for the detection of bacteria. Organic & Biomolecular Chemistry, 10 (13). pp. 2578-2589. ISSN 1477-0520

Gray, Mark, Piatek, A and Anslyn, E V (2004) Guanidinium Groups Act as General-Acid Catalysts in Phosphoryl Transfer Reactions: A Two-Proton Inventory on a Model System. J Am Chem Soc, 126 (32). pp. 9878-9879. ISSN 00027863

Gray, Mark, Goodman, A J, Carroll, J B and Bardon, K (2004) Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation. Organic Letters, 6 (3). pp. 385-388. ISSN 1523-7060

Gray, Mark, Cuello, A O, Cooke, G and Rotello, V (2003) Hydrogen Bonding in Redox-Modulated Molecular Recognition. An Experimental and Theoretical Investigation. J Am Chem Soc, 125 (26). pp. 7882-7888. ISSN 00027863

Gray, Mark, Legrand, Y, Cooke, G and Rotello, V (2003) Model Systems for Flavoenzyme Activity: Relationships between Cofactor Structure, Binding and Redox Properties. J Am Chem Soc, 125 (51). pp. 15789-15795. ISSN 00027863

Book Section

Tindle, John, Gray, Mark, Warrender, Robert, Ginty, Kevin and Dawson, Peter (2014) Further Development of an Application Framework for Computational Chemistry (AFCC) Applied to New Drug Discovery. In: Contemporary Advancements in Information Technology Development in Dynamic Environments. IGI Global, USA, pp. 92-210. ISBN 1466662522

Gray, Mark and Harburn, James (2011) Dynamic Covalent Chemistry in Fragment-based Drug Design. In: Encyclopedia of Supramolecular Chemistry. Taylor & Francis, pp. 1-9. ISBN 0-8247-5056-X

Kottakota, Suresh, Harburn, Jonathan, Guzman, J, Bhakta, S, Gray, Mark and Groundwater, Paul (2010) Synthesis of 20-N-methylpurpuramine E, an antitubercural metabolite from pseudoceratina sponge; paper no. b021. In: Proceedings of ECSOC-14, The Fourteenth International Electronic Conference on Synthetic Organic Chemistry. Sciforum Electronic Conferences Series . MDPI, Basel, Switzerland, pp. 1-9. ISBN 3-906980-24-3

Conference or Workshop Item

McMahon, Fiona, Dawson, Peter, Anderson, Rosaleen, Sattelle, Ben, Warrender, Robert and Gray, Mark (2015) Development of Functional Computational Workflow Methods for Quality Automated Molecular Modelling-based Drug Design. In: MGMS Young Modellers Forum 2015, 27 Nov 2015, Greenwich, London. (Submitted)

Patent

BIOMÉRIEUX (2019) Antibacterial compound and used of same. WO/2019/058074.

This list was generated on Tue Aug 4 20:35:37 2020 BST.

Last updated 11 June 2019

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