Principal Lecturer in Life Sciences and Team Leader (Bioscience and Environment)

My research is directed towards deciphering the molecular regulation of the cellular process of autophagy in the skin, specifically skin cancer and the inflammatory skin disorder psoriasis. My work has made original and translational contributions to cancer/dermatology research, highlighting novel biomarkers and therapeutic strategies to harness deregulated cell signalling for clinical benefit.

I am also committed to promoting public engagement with science and I am regularly involved in fund-raising for the North Eastern Skin Research Fund.

Teaching and supervision

I currently teach topics relating to chemistry, biochemistry and heamatology on the BSc Biomedical Science and BSc Healthcare Science (Life Sciences) programmes.

  • I am the module lead for Chemistry for the Biosciences, Blood Science, and Haematology & Transfusion Science. I also supervise students for stage 2 dissertations and stage 3 undergraduate research projects.

Research interests for potential research students

I am able to offer projects in areas related to my research in cancer biology and dermatological oncology, such as (but not restricted to) identification of diagnostic/prognostic biomarkers, drug targets, and cellular models of disease.

Research

The catabolic process of autophagy (self-eating) promotes cell survival and health, and deregulated autophagy is associated with numerous diseases, including cancer. My current research is directed towards deciphering the molecular regulation of autophagy in the skin. Research projects (in collaboration with Newcastle University, Complutense University (Madrid), and the University of Rome) include analysis of cell fate decisions in response to autophagy-inducing drugs (cannabinoids, dithranol) in cancer and psoriasis, as well as identification of prognostic biomarkers for skin cancer. In addition, our team have developed a 3D skin equivalent model (in collaboration with Reinnervate) to model melanoma progression in vitro.

Publications

Number of items: 24.

Article

Ellis, R, Tang, D, Nasr, B, Greenwood, A, McConnell, A, Anagnostou, ME, Elias, M, Verykiou, S, Bajwa, D, Ewen, T, Reynolds, NJ, Barrett, P, Carling, E, Watson, G, Armstrong, Jane, Allen, AJ, Horswell, S, Labus, M and Lovat, PE (2019) Epidermal AMBRA1 and Loricrin; a paradigm shift in the prognostication and stratification of AJCC stage I melanomas. British Journal of Dermatology. ISSN 1365-2133

Hernandez-Tiedra, Sonia, Fabrias, Gemma, Davila, David, Salanueva, Inigo J, Casas, Josefina, Montes, L Ruth, Anton, Zurine, Garcia-Taboada, Elena, Salazar-Roa, Maria, Lorente, Mar, Nylandsted, Jesper, Armstrong, Jane, Lopez-Valero, Israel, McKee, Christopher, Serrano-Puebla, Ana, Garcia-Lopez, Roberto, Gonzalez-Martinez, Jose, Abad, Jose L, Hanada, Kentaro, Boya, Patricia, Goni, Felix M, Guzman, Manuel, Lovat, Penny, Jaattela, Marja, Alonso, Alicia and Velasco, Guillermo (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy, 12 (11). pp. 2213-2229. ISSN 1554-8627

Klionsky, D.J., Armstrong, Jane and et al, (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1). pp. 1-222. ISSN 1554-8627

Hill, DS, Robinson, ND, Caley, MP, Chen, M, O'Toole, EA, Armstrong, Jane, Przyborski, S and Lovat, PE (2015) A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion. Molecular Cancer Therapeutics, 14 (11). pp. 2665-2673. ISSN 1535-7163

Hill, David S., Robinson, Neil D. P., Caley, Matthew P., Chen, Mei, O'Toole, Edel A., Armstrong, Jane, Przyborski, Stefan and Lovat, Penny E. (2015) A novel fully-humanised 3D skin equivalent to model early melanoma invasion. Molecular Cancer Therapeutics, 14 (9). ISSN 1535-7163

Armstrong, Jane, Hill, DS, McKee, CS, Hernandez-Tiedra, S, Lorente, M, Lopez-Valero, I, Eleni Anagnostou, M, Babatunde, F, Corazzari, M, Redfern, CP, Velasco, G and Lovat, PE (2015) Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. Journal Of Investigative Dermatology, 135 (6). pp. 1629-1637. ISSN 0022-202X

Ellis, R A, Horswell, S, Ness, T, Lumsdon, J, Tooze, S A, Kirkham, N, Armstrong, Jane and Lovat, P E (2014) Prognostic Impact of p62 Expression in Cutaneous Malignant Melanoma. Journal of Investigative Dermatology, 134 (5). pp. 1476-1478. ISSN 0022-202X

McKee, Christopher S, Hill, David S, Redfern, Christopher PF, Armstrong, Jane and Lovat, Penny E (2013) Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma. Experimental Dermatology, 22 (11). pp. 767-769. ISSN 1600-0625

O'Boyle, Graeme, Swidenbank, I, Marshall, H, Barker, CE, Armstrong, Jane, White, SA, Fricker, SP, Plummer, R, Wright, M and Lovat, PE (2013) Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. British Journal of Cancer, 108. pp. 1634-1640. ISSN 0007-0920

Wright, T J, McKee, C, Birch-Machin, M A, Ellis, R, Armstrong, Jane and Lovat, P E (2013) Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. Clinical and Experimental Dermatology. ISSN 1365-2230

Gomaa, M. S., Lim, A. S., Wilson Lau, S. C., Watts, A. M., Illingworth, N A, Bridgens, C. E., Veal, G. J., Redfern, C. P., Brancale, A, Armstrong, Jane and Simons, C. (2012) Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorganic & Medicinal Chemistry, 20 (20). pp. 6080-6081. ISSN 0968-0896

Gomaa, M., Bridgens, C., Illingworth, N., Veal, G. J., Redfern, C. P. F., Brancale, A, Armstrong, Jane and Simons, C. (2012) Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenyl-2-ylamino)phenyl)propyl scaffold. Bioorganic & Medicinal Chemistry, 20 (14). pp. 4201-4207. ISSN 0968-0896

Armstrong, Jane, Martin, S, Illingworth, N A, Jamieson, D, Neilson, A, Lovat, PE, Redfern, CPF and Veal, GJ (2011) The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide. Oncology Reports, 27. pp. 293-298. ISSN 1791-2431

Gomaa, M, Bridgens, C, Brancale, A, Veal, G J, Redfern, C P F, Armstrong, Jane and Simons, C (2011) Synthesis and Biological Evaluation of 3-(1H-Imidazol- and Triazol-1-yl)-2,2-Dimethyl-3-[4-(Naphthalen-2-ylamino)phenyl]propyl Derivatives as Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26). Journal of Medicinal Chemistry, 54 (19). pp. 6803-6811. ISSN 0022-2623

Armstrong, Jane, Corazzari, M, Martin, S, Pagliarini, V, Falasca, L, Hill, D S, Ellis, N, Al Sabah, S, Redfern, C P F, Fimia, G M, Piacentini, M and Lovat, P E (2011) Oncogenic B-RAF signalling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clinical Cancer Research, 17 (8). pp. 2216-2226. ISSN 1078-0432

Gomaa, M, Bridgens, C, Aboraia, A S, Veal, G J, Redfern, C P F, Brancale, A, Armstrong, Jane and Simons, C (2011) Small MolecuImidazole Methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. Journal of Medicinal Chemistry, 54 (8). pp. 2778-2791. ISSN 0022-2623

Hiscutt, E L, Hill, D S, Martin, S, Kerr, R, Harbottle, A, Simpson, D, Birch-Machin, M A, Redfern, C P F, Fulda, S, Armstrong, Jane and Lovat, P E (2010) Targeting XIAP to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy. Journal Of Investigative Dermatology, 130. pp. 2250-2258. ISSN 0022-202X

Armstrong, Jane, Flockhart, R, Veal, G J, Lovat, P E and Redfern, C P F (2010) Regulation of ER stress-induced cell death by ATF4 in neuroectodermal tumour cells. The Journal of Biological Chemistry, 285 (9). pp. 6091-6100. ISSN 0021-9258

Flockhart, R, Armstrong, Jane, Reynolds, NJ and Lovat, PE (2009) NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. British Journal of Cancer, 101 (8). pp. 1448-1455. ISSN 0007-0920

Hill, D S, Martin, S, Armstrong, Jane, Flockhart, R, Tonison, J J, Simpson, D G, Birch-Machin, M A, Redfern, C P F and Lovat, P E (2009) Combining the ER stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma. Clinical Cancer Research, 15 (4). pp. 1192-1198. ISSN 1078-0432

Armstrong, Jane, Lovat, P E, Corazzari, M, Martin, S, Pagliarini, V, Hill, D, Piacentini, M, Birch-Machin, M A and Redfern, C P F (2008) Increasing melanoma cell death using inhibitors of protein disulphide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Research, 68. pp. 5363-5369. ISSN 0008-5472

Conference or Workshop Item

Armstrong, Jane (2014) Cannabinoids hijack the autophagy pathway to promote melanoma cell death. In: The British Society for Investigative Dermatology, Annual Meeting 2014, 7 - 9 Apr 2014, Newcastle University Campus, Newcastle Upon Tyne. (Submitted)

Armstrong, Jane (2012) Invited Seminar, Blizard Institute. In: Centre for Cutaneous Research, Jun 2012, Barts & The London School of Medicine and Dentistry.

Armstrong, Jane (2012) Oral Presentation, British Society for Investigative Dermatology Annual Meeting. In: British Society for Investigative Dermatology Annual Meeting, 16 - 18 Apr 2012, University of Exeter.

This list was generated on Sat Jun 15 18:37:51 2019 BST.

Last updated 11 June 2019