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Dr David Swan

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Lecturer in Immunology

I am a Lecturer in Immunology in the School of Medicine. I teach the subject via lectures and workshops, facilitate problem-based learning, and provide pastoral support to students.

The human immune system is an incredible product of evolution. To have the opportunity to explain how it works to students – and to further our understanding of it through research – is a privilege.

Teaching and supervision

MBChB Medicine

  • Year 1: Innate Immunity; Adaptive Immunity; Mucosal Immunity
  • Year 2: Inflammation and Repair; Diseases of the Immune System; Gut Immunity; Hypersensitivity and Immunopathology

Research interests for potential research students

  • Monogenic disorders causing immunodeficiency and/or immune dysregulation
  • Autoimmunity


  • Finding the genetic causes and delineating the molecular mechanisms of novel primary immunodeficiencies
  • Discovering the changes in the immune system that are associated with disease flare in patients with relapsing-remitting autoimmune diseases
  • Developing therapies that restore self-tolerance in patients with autoimmune diseases


Jump to: Article
Number of items: 14.


Baker, Kenneth, McDonald, David, Hulme, Gillian, Hussain, Rafiqul, Coxhead, Jonathan, Swan, David, Schulz, Axel, Mei, Henrik, MacDonald, Lucy, Pratt, Arthur, Filby, Andrew, Anderson, Amy and Isaacs, John (2024) Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission. Nature Communications. ISSN ISSN 2041-1723

Ewen, Tom, Husain, Akhtar, Stefanos, Niki, Barrett, Paul, Jones, Claire, Ness, Tom, Long, Anna, Horswell, Stuart, Bosomworth, Helen, Lowenstein, Joe, Richardson, Grant, Swan, David, McConnell, Ashleigh, Rose, Aidan, Andrew, Tom, Reynolds, Nick, Malvehy, Josep, Carrera, Christina, Also, Llucia, Mailer, Sonia, Helm, Thomas, Ding, Liang, Bogner, Paul, Podlipnik, Sebastian, Puig, Susana, McArthur, Grant, Paragh, Gyorgy, Labus, Marie, Sloan, Philip, Armstrong, Jane and Lovat, Penny (2023) Validation of Epidermal AMBRA1 and Loricrin (AMBLor) as a prognostic biomarker for non-ulcerated AJCC stage I/II cutaneous melanoma. British Journal of Dermatology. ISSN 0007-0963

Swan, David, Aschenbrenner, Dominik, Lamb, Christopher A, Chakraborty, Krishnendu, Clark, Jonathan, Pandey, Sumeet, Engelhardt, Karin R, Chen, Rui, Cavounidis, Athena, Ding, Yuchun, Krasnogor, Natalio, Carey, Christopher D, Acres, Meghan, Needham, Stephanie, Cant, Andrew J, Arkwright, Peter D, Chandra, Anita, Okkenhaug, Klaus, Uhlig, Holm H and Hambleton, Sophie (2019) Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of -encoded phosphoinositide 3-kinase δ. Haematologica, 104 (10). e483-e486. ISSN 0390-6078

Anzilotti, Consuelo, Swan, David, Boisson, Bertrand, Deobagkar-Lele, Mukta, Oliveira, Catarina, Chabosseau, Pauline, Engelhardt, Karin R, Xu, Xijin, Chen, Rui, Alvarez, Luis, Berlinguer-Palmini, Rolando, Bull, Katherine R, Cawthorne, Eleanor, Cribbs, Adam P, Crockford, Tanya L, Dang, Tarana Singh, Fearn, Amy, Fenech, Emma J, de Jong, Sarah J, Lagerholm, B Christoffer, Ma, Cindy S, Sims, David, van den Berg, Bert, Xu, Yaobo, Cant, Andrew J, Kleiner, Gary, Leahy, T Ronan, de la Morena, M Teresa, Puck, Jennifer M, Shapiro, Ralph S, van der Burg, Mirjam, Chapman, J Ross, Christianson, John C, Davies, Benjamin, McGrath, John A, Przyborski, Stefan, Santibanez Koref, Mauro, Tangye, Stuart G, Werner, Andreas, Rutter, Guy A, Padilla-Parra, Sergi, Casanova, Jean-Laurent, Cornall, Richard J, Conley, Mary Ellen and Hambleton, Sophie (2019) An essential role for the Zn transporter ZIP7 in B cell development. Nature immunology, 20 (3). pp. 350-361. ISSN 1529-2916

Acres, Meghan J, Gothe, Florian, Grainger, Angela, Skelton, Andrew J, Swan, David, Willet, Joseph D P, Leech, Suzy, Galcheva, Sonya, Iotova, Violeta, Hambleton, Sophie and Engelhardt, Karin R (2018) Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain. Journal of allergy and clinical immunology, 143 (1). 413-416.e4. ISSN 0091-6749

Duncan, Christopher J A, Dinnigan, Emma, Theobald, Rachel, Grainger, Angela, Skelton, Andrew J, Hussain, Rafiqul, Willet, Joseph D P, Swan, David, Coxhead, Jonathan, Thomas, Matthew F, Thomas, Julian, Zamvar, Veena, Slatter, Mary A, Cant, Andrew J, Engelhardt, Karin R and Hambleton, Sophie (2018) Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in (A20). Annals of the rheumatic diseases, 77 (5). pp. 783-786. ISSN 1468-2060

Taylor, K, Swan, David, Affleck, A, Flohr, C and Reynolds, N J (2017) Treatment of moderate-to-severe atopic eczema in adults within the U.K.: results of a national survey of dermatologists. The British journal of dermatology, 176 (6). pp. 1617-1623. ISSN 0007-0963

Engelhardt, Karin R, Xu, Yaobo, Grainger, Angela, Germani Batacchi, Mila G C, Swan, David, Willet, Joseph D P, Abd Hamid, Intan J, Agyeman, Philipp, Barge, Dawn, Bibi, Shahnaz, Jenkins, Lucy, Flood, Terence J, Abinun, Mario, Slatter, Mary A, Gennery, Andrew R, Cant, Andrew J, Santibanez Koref, Mauro, Gilmour, Kimberly and Hambleton, Sophie (2017) Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing. Journal of clinical immunology, 37 (1). pp. 42-50. ISSN 1573-2592

Anderson, A E, Swan, David, Wong, O Y, Buck, M, Eltherington, O, Harry, R A, Patterson, A M, Pratt, A G, Reynolds, G, Doran, J-P, Kirby, J A, Isaacs, J D and Hilkens, C M U (2016) Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4 T cells partly via transforming growth factor-β1. Clinical and experimental immunology, 187 (1). pp. 113-123. ISSN 0009-9104

Milner, Joshua D., Vogel, Tiphanie P., Forbes, Lisa, Ma, Chi A., Stray-Pedersen, Asbjørg, Niemela, Julie E., Lyons, Jonathan J., Engelhardt, Karin R., Zhang, Yu, Topcagic, Nermina, Roberson, Elisha D. O., Matthews, Helen, Verbsky, James W., Dasu, Trivikram, Vargas-Hernandez, Alexander, Varghese, Nidhy, McClain, Kenneth L., Karam, Lina B., Nahmod, Karen, Makedonas, George, Mace, Emily M., Sorte, Hanne S., Perminow, Gøri, Rao, V. Koneti, O’Connell, Michael P., Price, Susan, Su, Helen C., Butrick, Morgan, McElwee, Joshua, Hughes, Jason D., Willet, Joseph, Swan, David, Xu, Yaobo, Santibanez-Koref, Mauro, Slowik, Voytek, Dinwiddie, Darrell L., Ciaccio, Christina E., Saunders, Carol J., Septer, Seth, Kingsmore, Stephen F., White, Andrew J., Cant, Andrew J., Hambleton, Sophie and Cooper, Megan A. (2015) Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood, 125 (4). pp. 591-599. ISSN 0006-4971

Swan, David, Kirby, John A and Ali, Simi (2012) Post-transplant immunosuppression: regulation of the efflux of allospecific effector T cells from lymphoid tissues. PloS one, 7 (9). e45548. ISSN 1932-6203

Swan, David, Kirby, John A and Ali, Simi (2010) Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. Journal of cellular and molecular medicine, 14 (9). pp. 2211-22. ISSN 1582-4934

Anderson, Amy E, Swan, David, Sayers, Bethan L, Harry, Rachel A, Patterson, Angela M, von Delwig, Alexei, Robinson, John H, Isaacs, John D and Hilkens, Catharien M U (2008) LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells. Journal of leukocyte biology, 85 (2). pp. 243-50. ISSN 0741-5400

Anderson, Amy E, Sayers, Bethan L, Haniffa, Muzlifah A, Swan, David, Diboll, Julie, Wang, Xiao-Nong, Isaacs, John D and Hilkens, Catharien M U (2008) Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells. Journal of leukocyte biology, 84 (1). pp. 124-133. ISSN 0741-5400

This list was generated on Mon Jul 22 07:03:41 2024 BST.

  • Control of lymphocyte migration
  • Signalling in lymphocyte development
  • Regulation of T cell responses by dendritic cells

Last updated 30 May 2024