Drug discovery and pharmaceutical sciences

Our research in drug discovery and pharmaceutical sciences aims to translate fundamental science into novel biomarkers or pharmaceutical interventions for the diagnosis and treatment of human disease. Our research within molecular and cellular biology, analytical and medicinal chemistry, and pharmaceutics, has attracted funding from a range of charities, the Medical Research Council, Innovate UK, and industry.

Molecular medicine and drug discovery

Research focusses on understanding pathological processes underlying disease and the biological rationale for biomarker and target selection, across a spectrum of metabolic disease, cancer, autoimmune disease and infection. Further work on translating basic research findings includes target validation studies and the design and characterisation of small molecule inhibitors or prodrugs, as well as the development of approaches to deliver stratified and personalised medicines.

Pharmaceutical formulation and drug delivery strategies

Research is directed towards development of technologies and approaches designed to improve pharmaceutical manufacturing processes, such as cost or ease of production, overcoming the challenges faced with the formulation of both small and large drug molecules into suitable, patient compliant dosage forms for patient benefit, as well as improved insulin stability and delivery.

We have been successful in closing the gap in ‘bench to bedside’ communication and the translation of basic laboratory findings into pre-clinical development, while our experience in facilitating knowledge exchange across disciplines has led to successful industrial collaborations.